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Tuesday, August 4, 2020 | History

4 edition of Anti-asthma Xanthines and Adenosine (Current clinical practice series) found in the catalog.

Anti-asthma Xanthines and Adenosine (Current clinical practice series)

Anti-asthma Xanthines and Adenosine (Current clinical practice series)

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Published by Elsevier .
Written in English


Edition Notes

ContributionsK-.E. Andersson (Editor), C.G.A. Persson (Editor)
The Physical Object
Number of Pages512
ID Numbers
Open LibraryOL7534219M
ISBN 100444904395
ISBN 109780444904393

A one-pot route to 8-substituted xanthines has been developed from 5,6-diaminouracils and carboxaldehydes. Yields are good and the process applicable to a range of substrates including a family of A 2A adenosine receptor antagonists.A new route to the KW family of antagonists is presented including a pro-drug variant, and application to related image contrast agents developed. The effects of xanthine and adenosine analogs were tested on isolated, electrically stimulated diaphragms from four- to seven-day-old rat pups. The effects of direct vs. indirect (phrenic nerve) stimulation were studied in the presence of varying concentrations of caffeine. The directly stimulated diaphragms had significantly larger increases.

Xanthine (/ ˈ z æ n θ iː n / or / ˈ z æ n θ aɪ n /; archaically xanthic acid; systematic name 3,7-dihydropurine-2,6-dione) is a purine base found in most human body tissues and fluids and in other organisms. Several stimulants are derived from xanthine, including caffeine, theophyline, and theobromine.. Xanthine is a product on the pathway of purine degradation.. It is created from. STIMULANTS: Methylxanthines/Xanthines (p.1) (“minor” stimulants) 1. Plant Sources of Xanthines (alkaloids) Coffee – Coffea Arabica (Ethiopia originally) Coffea robusta (African Congo originally) Tea – Camellia sinensis (China, India, Burma, Thailand, Laos & Vietnam) Chocolate – Theobroma cacao (Amazon & Orinoco rivers) Holly – Ilex guayusa (Amazon, Peru, Ecuador).

The improvement in lung function after 24 hours did not differ between treatments suggesting that the high levels of enprofylline were supramaximal for its anti-asthma effects in this situation. In conclusion, with enprofylline it is demonstrated that an adenosine non-blocking xanthine derivative may lack CNS-excitatory effects, but be more.   Xanthines bind to the same receptors as adenosine (antagonism), which prevents this effect and keeps us alert and awake. Also, maintaining a high level of circulating cAMP may increase heart rate and promote fat metabolism. Xanthines Health Benefits Effective: 1) Respiratory Conditions.


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Anti-asthma Xanthines and Adenosine (Current clinical practice series) Download PDF EPUB FB2

In: Andersson KE, Persson CGA (eds) Anti-asthma xanthines and adenosine. Amsterdam, Excerpta, pp – Google Scholar. Barclay J, Whiting B, Addis GJ () The influence of theophylline on maximal response to salbutamol in Anti-asthma Xanthines and Adenosine book chronic obstructive pulmonary by: Anti-asthma xanthines and adenosine.

Amsterdam ; Princeton: Excerpta Medica ; New York, NY, USA: Sole distributors for the USA and Canada, Elsevier Science Pub. Co., (OCoLC) Online version: Anti-asthma xanthines and adenosine. Naturally occuring xanthines. The earliest adenosine receptor (AR) antagonists identified were the naturally-occurring alkylxanthines, most notably among these being caffeine (1,3,7-trimethylxanthine, 1) and theophylline (1,3-dimethylxanthine, 2) (see Fig.

1) (Daly ; Fredholm ; Stefanovich ).Another simple natural xanthine, theobromine (3) was shown to have only weak activity Cited by: The monosubstituted 3-aminoalkoxyl 8-phenyl xanthine with a diethylmoiety (compound 12e) was found to be most potent A2A adenosine receptor ligand (Ki = µM) followed by disubstituted 4.

Andersson P, Brange C, Sonmark B, Stare G, Erjefalt I, Wieslander E, Persson C.G.A.,Anti-anaphylactic and anti-inflammatory effects of xanthines in the lung, In: Andersson KE, Persson CGA (eds).

Anti-asthma xanthines and adenosine. Amsterdam, Excerpta, pp Google Scholar. : Guy F. Joos, Romain A. Pauwels. Request PDF | Sympathomimetics and Xanthines in the Treatment of Asthma | Sympathomimetics and xanthines are widely used in the treatment of both acute and chronic asthma.

They are generally. WebMD provides information about interactions between Anti-Asthma Oral and xanthine-derivatives-adenosine-hexobendine-regadenoson. Enprofylline, a drug without adenosine antagonism and theophylline, a potent adenosine antagonist, were compared, double-blind, randomized, in acute asthma (n = 33).

The drugs were given intravenously as loading over 10 min followed by maintenance infusion for 24 h. Mean final plasma levels were very high with enprofylline (14 mg.l), and larger than calculated with theophylline (16 mg.l).

It is ethylated xanthine (dioxy purine) structurally related to uric acid. Solubility of methyl xanthine is low and is enhanced by formation of complex with ethylene diamine in Theophylline + Ethylene diamine = Aminophylline. Mechanism of Action. Inhibit Phosphodiestrase Enzyme. Life Sciences, Vol.

46, pp. Pergamon Press Printed in the U.S.A. MECHANISM FOR THE EMETIC SIDE EFFECT OF XANTHINE BRONCHODILATORS Ralph E. Howell, William T. Muehsam and William J. Kinnier NOVA Pharmaceutical Corporation Freeport Centre Baltimore, Maryland (Received in fin~l form Decem ) Summary The.

Xanthines as Adenosine Receptor Antagonists. , DOI: /_6. Rashad Al-Salahi, Detlef Geffken, Maria Koellner. A New Series of 2-Alkoxy(aralkoxy)-[1,2,4]triazolo[1,5-a]quinazolinones as Adenosine Receptor Antagonists.

Platelet‐activating factor (PAF) may be involved in the pathogenesis of asthma, and therefore the effects of the anti‐asthma drugs theophylline and enprofylline on human platelet aggrega XANTHINES INHIBIT HUMAN PLATELET AGGREGATION INDUCED BY PLATELET‐ACTIVATING FACTOR - Misso - - Clinical and Experimental Pharmacology and.

Xanthines (also known as substituted xanthines) are a chemical class of psychoactive substances derived from xanthine, an organic compound found in most human body tissues and fluids as well as in other organisms.

Examples of xanthines include caffeine and theobromine.[1] These are commonly used for their effects as both stimulants and bronchodilators. I read with interest the excellent update on adenosine by Polosa and Holgate.1 An important use of this challenge agent is demonstrated and adenosine antagonism as a potential treatment for asthma is revisited.

However, the role of adenosine as a mediator of asthma is somewhat inconsistent with several functional observations. Besides the fact that adenosine has dual effects in many systems. enprofylllne were supramaximal for its anti-asthma effects in this situ­ ation. In conclusion, with enprofylllne it Is demonstrated that an adenosine non-blocking xanthine derivative may lack CNS-excltatory effects, but be more potent than theophylline In the treatment of.

Based on the adenosine receptor-antagonistic activity of these compounds, it can be raised that xanthine derivatives might inhibit the cardioprotective action of endogenous adenosine on various subtypes (A1, A2A, A2B and A3) of adenosine receptors.

The Importance of?2-Adrenoceptor Selectivity and Efficacy -- G. Adverse Reactions to?-Adrenoceptor Agonists -- H. Therapeutic Actions of?-Agonists -- I. Concluding Remarks -- References -- 7 Pharmacology of Anti-Asthma Xanthines -- A. Introduction -- B. Clinical Use -- C.

Mode of Action of Xanthines -- D. Conclusion -- References -- 8. Pharmacology of Asthma by Clive P. Page,available at Book Depository with free delivery worldwide. The xanthines, which are purine analogues, are non-selective inhibitors of phosphodiesterase and also antagonists at adenosine receptors.

Owing to their ability to relax bronchial muscles, the xanthines are used chiefly in the maintenance treatment of asthma and chronic obstructive pulmonary disease. The exact mechanism of action of xanthines, and theophylline in particular, is unknown. 7 It was originally thought that xanthines caused smooth muscle relaxation by inhibition of phosphodiesterase (PDE), leading to an increase in intracellular cyclic adenosine 3′,5′-monophosphate (cAMP).

An increase in cAMP causes relaxation of bronchial. Report by Polly Terry, Specialist Registrar Search checked by Gail Lumsden, Specialist Registrar A 32 year old woman with asthma presents to the emergency department with a 20 minute history of palpitations.

On examination she is cardiovascularly stable, there is no bronchospasm and the ECG shows a supraventricular tachycardia (SVT) that fails to respond to vagal manoeuvres.At both types of adenosine receptors, alkylxanthines (theophylline and caffeine being the prototypes) are competitive antagonists.

These classical xanthines show affinities in the 10 −5 —10 −4 m range and show little or no selectivity for either receptor type (Fredholm & Persson ).Fluorosulfonyl-Substituted Xanthines as Selective Irreversible Antagonists for the A1-Adenosine Receptor.

Journal of Medicinal Chemistry43 (26),